TB – 500 (5 MG)

(15 customer reviews)


Molecular formula: C212H350N56O78S
Molar Mass: 4963.4408
CAS number: 77591-33-4

Thymosin Beta 4, or TB-500, is a synthetic version of a naturally occurring 43-amino acid peptide present in nearly all human and animal cells studied. A 2010 study in the Annals of the New York Academy of Sciences supported TB500’s potential for cardiac muscle  repair following injury, eg, after myocardial infarction (heart attack). Recognizing the limitations of stem cell therapy for this application, TB500 was found to inhibit myocardial cell death, stimulate blood vessel growth, and activate cardiac processes that encouraged the heart to heal following injury.


TB-500 Research Studies

The investigation showed that TB500 may be the first agent which can actively recover injured cardiac muscle following heart attack. This is further supported with prior mouse studies in 2004 showing cardiomyocyte migration, survival and repair of myocardial damage. [1] [2]

Filamentous actin (F-actin, or actin) forms polymers that thicken sputum, adversely affecting cystic fibrosis patients. TB500 was studied in a population of CF patients, showing a dose and time-dependent decrease in cohesivity of sputum after administration of TB500 when combined with dornase alfa. The combination therapy showed a 71% improvement in mucociliary transport of mucus, and a 44% improvement in cough transport of mucus. [3]

TB500 is known to stimulate myoblasts and myocytes (muscle generating cells). Mitochondrial RNA levels of TB500 have been shown to increase following muscle injury, helping to regenerate muscle fibers and address inflammation in the injured location. The data support muscle injury causing increased local production of TB500, promoting migration of incoming myoblasts to accelerate skeletal muscle regeneration. [4]

A study completed in 2009 using .01% TB500 w/w eye drops demonstrated increased speed of healing following eye surgery in diabetics. This population was specifically investigated due to well-known healing complications in diabetics, and their predilection for eye issues, specifically diabetic retinopathy. The study showed no serious side effects in any patient, although headache, dizziness and insomnia occurred more in the study group than the control. Of specific interest, human diabetic retinopathic corneas express substantially less endogenous TB500 than a normal cornea, suggesting an inherent deficiency in ability for diabetics to heal following eye injury or surgery. [5]

Similarly, chronic dry-eye patients were treated with TB500 eye drops, and all in the study had improvement in symptoms, with rare and minimal complications. [6]

TB500 was studied in the setting of chronic hepatitis B combined with nonalcoholic fatty liver disease (NAFLD). While TB500 had no correlation with HepB Virus levels nor liver function tests (AST, ALT, TG), there was a negative correlation with inflammation and fibrosis scores – meaning that the lower the level of TB500, the worse the inflammation and fibrosis. This provided preliminary data that TB500 may be beneficial in the setting of certain liver diseases.[7]

A human voluntary safety and tolerance study was performed in 2010, and showed that intravenous (IV) doses from 42mg up to 1260mg daily for 14 days had no treatment related adverse effects, and no evidence of dose related toxicity. [8]

Rhinovirus (a common cold virus) was introduced to healthy volunteers, and blood tests were taken during a five-day period. This showed that serum cortisol rose along with thymosin alpha 1 and TB500 on the fifth day following intentional exposure. Simultaneously, T lymphocytes (CD3+), cytotoxic/suppressor (CD8+), and natural killer (CD16+) cells all rose. This suggests a cooperative effect among systemic and cellular immune response related to thymosin and respiratory virus exposure. [9]

Kidney disease often includes inflammation, fibrosis, and complications from diabetes. TB500 has been studied in mice with and without kidney disease; in healthy mice, levels of TB500 did not affect healthy kidney tissue, but in those with known kidney disease, low levels of TB500 correlated with worsening disease. That is, low levels of natural TB500 accelerated kidney disease. The study suggested that endogenous TB500 levels function to protect the kidney and slow disease progression. [10]

TB500 has been studied specifically in healing of skin and wounds, showing acceleration in healing of skin in burns, diabetic ulcers, elderly subjects, pressure ulcers, stasis ulcers, and epidermolysis wounds, in both animal and human subjects. The study shows improvement in angiogenesis (blood vessel formation), anti-inflammatory activity, and to increase platelet aggregation at wound sites. [11]


1 – Medicine (Baltimore).2016 Dec;95(52):e5763. doi: 10.1097/MD.0000000000005763. The expression of thymosin β4 in chronic hepatitis B combined nonalcoholic fatty liver disease. Liang J1, Cai W, Han T, Jing L, Ma Z, Gao Y.

2 – Nature. 2004 Nov 25;432(7016):466-72. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Bock-Marquette I1, Saxena A, White MD, Dimaio JM, Srivastava D.

3 – Chest. 2006 Nov;130(5):1433-40. Thymosin beta4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitro. Rubin BK1, Kater AP, Goldstein AL.

4 – J Biochem. 2011 Jan;149(1):43-8. doi: 10.1093/jb/mvq115. Epub 2010 Sep 29. Muscle injury-induced thymosin β4 acts as a chemoattractant for myoblasts. Tokura Y1, Nakayama Y, Fukada S, Nara N, Yamamoto H, Matsuda R, Hara T.

5 – https://clinicaltrials.gov/show/NCT00598871

6 – Ann N Y Acad Sci. 2010 Apr;1194:199-206. doi: 10.1111/j.1749-6632.2010.05471.x. Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta4. Dunn SP1, Heidemann DG, Chow CY, Crockford D, Turjman N, Angel J, Allan CB, Sosne G.

7 – Ann N Y Acad Sci. 2010 Apr;1194:87-96. Thymosin beta4 and cardiac repair. Shrivastava S1, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I.

8 – Ann N Y Acad Sci. 2010 Apr;1194:223-9. doi: 10.1111/j.1749-6632.2010.05474.x. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Ruff D1, Crockford D, Girardi G, Zhang Y.

9 – Lymphokine Res. 1989 Winter;8(4):383-91. Modulation of thymosin alpha 1 and thymosin beta 4 levels and peripheral blood mononuclear cell subsets during experimental rhinovirus colds. Hsia J1, Sztein MB, Naylor PH, Simon GL, Goldstein AL, Hayden FG.

10 – Kidney Int. 2016 Nov;90(5):1056-1070. doi: 10.1016/j.kint.2016.06.032. Epub 2016 Aug 26. Loss of endogenous thymosin β4 accelerates glomerular disease. Vasilopoulou E1, Kolatsi-Joannou M1, Lindenmeyer MT2, White KE3, Robson MG4, Cohen CD2, Sebire NJ1, Riley PR5, Winyard PJ1, Long DA6.

11 – Vitam Horm. 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24.


15 reviews for TB – 500 (5 MG)

  1. Harold

    These guys consistently deliver and over perform. We have been very happy. Perfect, Clean, every time! Thanks for this TB – 500 peptide.

  2. Ron

    TB-500 is Excellent product for healing.

  3. Chad

    TB-500 genuinely Heals extremely well. Great product for sure.

  4. Jacob

    I have no complains with this company. Just a great company delivering exactly what I ordered.

  5. Mitchell

    After several weeks of treatment using TB 500 twice a week at 5mg per treatment, joint pain has relief improved as well as flexibility.

  6. Lee

    My dog was suffering from a chronic low back, disc issue, right knee pain from several prior surgeries and this formula has our dog active, able to run and play. Thanks peptide for sale for this peptide.

  7. Roland

    This is really a great product, item is professionally packed and shipped.

  8. Melvin

    I’ve seen a noticeable difference in soreness and mobility after the first few doses.

  9. Arnold

    Already feeling a lot better. This TB-500 peptide is really promising.

  10. Alfred

    This peptide is giving myself and my wife the opportunity to heal our dog. Massive Improvement with TB 500 and BPC 157 in first 15 days.

  11. Harvey

    Using this once a month has helped my pet regain his range of motion allowing him to do the simple things like go up stairs again. Definitely a great source to buy peptides.

  12. Kyle

    Nothing bad to say. This stuff does exactly what it says it doe. A high quality product.

  13. Francis

    This stuff works . In tandem with BPC157, has given me my shoulders back.

  14. Adrian

    I’ve ordered several times from this company. really impressed with their fast service and quality products.

  15. Samuel

    TB-500 has shown potential in our research for accelerating recovery from workouts and injuries. We’re very happy with the results and will reorder for further studies.

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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.