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Sequence: Glu-Asp-Arg
Molecular Formula: C15H26N6O8
Molecular Weight: 418.407 g/mol
PubChem CID: 18220191

Pinealon is a short peptide consisting of just three amino acids. It is one of a handful of synthetic peptides referred to as peptide bioregulators for their ability to interact directly with DNA to alter gene expression levels. Pinealon has been linked to behavior modification and is thought to help protect several cell types, including neurons, against the effects of hypoxia. By direct effect on the pineal gland, Pinealon may reduce problems with drug metabolism, circadian rhythm disorders, memory, learning, and more.


Unraveling the Potential of the Pinealon Peptide

So, you’re interested in the Pinealon peptide? Good for you! It’s a remarkable molecule with a broad range of potential applications. It’s a rabbit hole of biological wonder that we’re about to jump right into. Hold onto your hats, folks, because it’s going to be a wild ride. 

Peptides in a nutshell

Peptides. These little guys are short chains of amino acids, the building blocks of proteins. They’re like the secret agents of the body, carrying out crucial functions and sending vital messages. 

The Pinealon peptide is a remarkable compound

Pinealon is a veritable game-changer in the world of medical research. It’s a nootropic peptide – a brain-boosting molecule that’s been making waves in the medical community. But what’s so special about it? Let’s dig a little deeper. Understanding Peptides Before we dive headfirst into Pinealon,  What Makes Pinealon Peptide Unique? The Pinealon peptide is like the Swiss Army knife of peptides. It’s derived from the proteins in the pineal gland, a small endocrine gland in the brain. This gland is often referred to as the “third eye” because of its role in regulating the body’s internal clock. 

Memory and Cognitive Enhancement 

The Pinealon peptide has been linked to potential improvements in memory and cognitive function. Like a deft conductor leading a symphony, it orchestrates a host of brain activities, potentially enhancing overall performance.

Potential Role in Aging 

The Pinealon peptide might be the closest thing we have to a fountain of youth. Preliminary studies suggest it may play a role in slowing down the aging process, but more research is needed to fully understand this potential benefit. The Science Behind the Pinealon Peptide Science is at the heart of understanding the Pinealon peptide. 

The Pineal Gland Connection 

The Pinealon peptide has its roots in the pineal gland. This gland, tucked away in our brains, is a powerhouse of activity, controlling a variety of bodily functions. The Magic of Melatonin.  The Pinealon peptide is closely linked to melatonin, a hormone produced in the pineal gland. Like two peas in a pod, these compounds work together to regulate sleep and circadian rhythms. 

Exploring the Use of Pinealon Peptide Like a multi-tool

Let’s explore some of the possibilities. As a Nootropic Pinealon peptide is often used as a nootropic, enhancing cognitive function and memory. It’s like a mental gym workout, helping to keep the brain fit and healthy. The Pinealon peptide may have potential therapeutic uses. From age-related cognitive decline to sleep disorders, it could be a powerful tool in the medical toolkit. 

Understanding the Safety of Pinealon Peptide 

With great power comes great responsibility. Let’s take a closer look at the safety of the Pinealon peptide. The peptide may have side effects. However, current research suggests it is relatively safe. Always remember, though, it’s crucial to consult with a healthcare professional before starting any new supplement or treatment. Potential Interactions between Pinealon and other substances are not yet fully understood. As we always say, better safe than sorry. 

Pinealon FAQs

Q: What is the Pinealon peptide? 

A: The Pinealon peptide is a nootropic peptide derived from proteins in the pineal gland. It’s been linked to potential benefits such as cognitive enhancement and potentially slowing down the aging process.

Q: How is the Pinealon peptide used?

A: The Pinealon peptide is often used as a nootropic to potentially enhance cognitive function and memory. It may also have therapeutic uses in treating age-related cognitive decline and sleep disorders.

Q:  Is Pinealon safe?

A:  Current research suggests Pinealon is relatively safe. However, it’s always best to consult with a healthcare professional before starting any new supplement or treatment.

Q:  Does the Pinealon peptide have any side effects?

A:  Like any compound, the Pinealon peptide may have side effects. But so far, it appears to be well-tolerated in research settings.

Q: Where does the Pinealon peptide come from? 

A: The Pinealon peptide is derived from proteins in the pineal gland, a small endocrine gland in the brain.

Q:  What’s the connection between the Pinealon peptide and melatonin?

A: The Pinealon peptide is closely linked to melatonin, a hormone produced in the pineal gland. They work together to regulate sleep and circadian rhythms. 

Pinealon is a fascinating compound that has the potential to revolutionize our understanding of cognitive function, aging, and overall brain health. But remember, while it’s an exciting area of research, we’re just scratching the surface. As we continue to unlock the secrets of the Pinealon peptide, who knows what we’ll discover next? It’s like we’re standing at the edge of a vast ocean, waiting to plunge into the depths. The future of Pinealon is as exciting as it is unknown. Remember to keep an open mind, stay curious, and always seek knowledge. In the world of peptides, there’s always more to learn. So, until next time, keep exploring!

Author Bio:

Aero is a peptides researcher based in New Orleans. With years of experience in the field, Aero has developed a deep understanding of peptides and their potential applications. He conducts cutting-edge research on peptides in a private lab, where he is dedicated to advancing the field and exploring new avenues for therapeutic use.

In his free time, Aero enjoys staying up to date on the latest developments in the field of peptides research. He also volunteers with local organizations and is committed to making a positive impact in his community.

Aero holds a degree in biochemistry from a top-tier university and has published numerous articles in leading scientific journals. His expertise has been recognized by his peers, and he has been invited to speak at conferences around the world.

Overall, Aero is a passionate researcher who is committed to advancing the field of peptides and making a difference through his work.




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Pinealon Interacts Directly with DNA

Unlike most peptides, Pinealon does not appear to bind to cell surface or cytoplasmic receptors. This has led scientists to wonder how the short peptide can have any effect. In the past, it was suggested that Pinealon may be small enough to cross lipid bilayers (e.g. the cell membrane, nuclear membrane) and may therefore be able to interact directly with DNA. Testing in cell cultures (HeLa cells) indicates that Pinealon directly penetrates the cell membrane as well as the nuclear membrane to interact with DNA[1]. This makes Pinealon a regulator of gene expression and explains the peptide’s myriad effects that cannot be explained by receptor interactions.

Pinealon Research into Aging 

Pinealon may have anti-aging effects in the central nervous system. Research from Russia indicates that Pinealon and a similar peptide, Vesugen, are anabolic in the brain and can slow the rate of aging when calculated using biological age indicators[2].

Pinealon is active in cells outside of the central nervous system as well. Research shows that the peptide also has effects on muscle cells where it alters the expression of irisin[3].

Irisin is important to protecting muscle cells during exercise, promotes fat burning, and is thought to induce telomere elongation as well. By increasing the lifespan of irisin, Pinealon boosts telomere protection and helps to fight off the effects of aging and oxidative stress. In fact, plasma irisin levels are directly linked to telomere length in healthy adults and levels of the enzyme have been directly linked to calorie restriction, one of the few activities known beyond doubt to prolong life and improve overall fitness[4].

Interestingly, there is evidence that irisin is active outside of muscle cells and that Pinealon may therefore have anti-aging effects that are broadly distributed throughout the body, including the brain.

Pinealon Research and Neuron Protection

Research in prenatal rats indicates that Pinealon protects neurons against oxidative stress and thus protects cognitive function and motor coordination[5]. The study showed marked decreases in both reactive oxygen species accumulation as well as number of necrotic cells in the brain in these rats. In other words, Pinealon protects neurons from dying.

Research suggest that Pinealon protects against reactive oxygen species and reduces necrotic cell death also came with the understanding that the peptide modifies the cell cycle as part of its protection against cell death[6].

This was one of the first indications that Pinealon was almost certainly interacting at the level of DNA. Interestingly, Pinealon modulates the cell cycle by activating proliferation pathways. Under normal circumstances, this would lead to an increase in cell number, but under the setting of oxidative stress, this effect simply offsets some of the damaging effects of reactive oxygen species. Research in adult rats deprived of oxygen has also shown that Pinealon increases the resistance of neurons to hypoxic stress. It appears to do this by stimulating innate anti-oxidative enzyme systems and limiting the excitotoxic effects of N-methyl-D-aspartate[7]. Nmethyl-D-aspartate (NMDA) is an amino acid derivative that can kill nerve cells by over-exciting them. NMDA has been shown to become overactive during withdrawal from alcohol and is at least partly responsible for the “shakes” or delirium tremors that affects chronic alcoholics during withdrawal. NMDA has been linked to nerve death in traumatic brain injury and ischemic stroke.

Irisin, which has been discussed in the context of muscle cell protection, has recently been found in the brain where it plays important roles in neural differentiation, proliferation, and energy expenditure. Irisin levels in the central nervous system has been found to stimulate genes in the hippocampus that are important to memory, learning, the overall neuron health[8].

Research in rats suggests that exercise directly boosts levels of irisin in the brain, which may finally provide the link between physical activity and cognition. Scientists have speculated that irisin is the messenger that mediates crosstalk between skeletal muscle and the central nervous system during exercise. Pinealon boosts levels of irisin by altering expression of the gene that codes for the enzyme. This leads to increased levels of irisin through prolonged lifespan of the enzyme.

Pinealon research and Depression

Research in cultures of brain cortex cells indicate that Pinealon can boost expression of 5-tryptophan hydroxylase via epigenetic changes. 5-tryptophan hydroxylase is critical to the production and secretion of serotonin, a peptide known to have neuroprotective and geroprotective features[9].

It is also the signaling molecule most often targeted by anti-depressive drugs called selective-serotonin reuptake inhibitors (SSRIs). SSRIs have a number of side effects, however, and the ability to boost serotonin production organically could offer a means of fighting depression that is more physiologic and thus reduce side effects.

Pinealon Protects Cells from Caspase-3 and Cell Death

The initial understanding that Pinealon could affect the cell cycle came from research into the effects of the peptide in rat models of ischemic stroke. These studies revealed that Pinealon affects cytokine signaling that normally leads to an increase in levels of the caspase-3 enzyme[10].

Caspase-3 is directly responsible for initiating apoptosis, or the controlled death of a cell via genetic instruction. By modulating caspase-3, Pinealon shuts down at least one pathway to cell death and thus reduces the effects of oxygen deprivation during stroke. Caspase-3 is not only active in neurologic tissue though, but also almost universal. Research using models of heart attack indicates that Pinealon may reduce caspase-3 levels following myocardial infarction[11]. The short peptide may have application both in treating heart attack and in preventing the long-term remodeling that causes so much dysfunction following a myocardial infarction.

The benefit of Pinealon in suppressing caspase-3 expression has been demonstrated in skin cells. By reducing apoptosis in the skin, Pinealon promotes cell proliferation in both young and old animals alike. This leads to an increase in the regenerative process and has been shown to offset age-related pathology in the skin[12]. Pinealon may eventually form part of a multi-faceted approach to wound healing and could have application in everything from sun protection to serious burn treatment.

Pinealon Research and Sleep Regulation

Pinealon affects that sleep-wake cycle as well as sleep behavior. Research indicates that Pinealon may help to regulate the dysfunction caused by shiftwork and other activities (e.g. long-distance travel) that interfere with normal sleep patterns. The peptide appears to reset the pineal gland to baseline in the setting of circadian rhythm disruption, improving sleep, depression, mood, blood pressure, and more as a result[13].

The ability to regulate sleep corresponds strongly with rates of aging. Disturbed sleep is a recipe for disaster in the body and affects cognition, cardiac health, wound healing, mood, and more. Pinealon may therefore help to reduce the impact of sleep disturbance and thus offset the effects that it has on aging. This could be beneficial not only to those forced into disorder sleep due to their jobs, but to individuals suffering from organic disease that impacts sleep-wake cycles.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Vladimir Khavinson is a Professor, President of the European region of the International Association of Gerontology and Geriatrics; Member of the Russian and Ukrainian Academies of Medical Sciences; Main gerontologist of the Health Committee of the Government of Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice-president of Gerontological Society of the Russian Academy of Sciences; Head of the Chair of Gerontology and Geriatrics of the North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired. Vladimir Khavinson is known for the discovery, experimental and clinical studies of new classes of peptide bioregulators as well as for the development of bioregulating peptide therapy. He is engaged in studying of the role of peptides in regulation of the mechanisms of ageing. His main field of actions is design, pre-clinical and clinical studies of new peptide geroprotectors. A 40-year-long investigation resulted in a multitude of methods of application of peptide bioregulators to slow down the process of aging and increase human life span. Six peptide-based pharmaceuticals and 64 peptide food supplements have been introduced into clinical practice by V. Khavinson. He is an author of 196 patents (Russian and international) as well as of 775 scientific publications. His major achievements are presented in two books: “Peptides and Ageing” (NEL, 2002) and “Gerontological aspects of genome peptide regulation” (Karger AG, 2005). Vladimir Khavinson introduced scientific specialty “Gerontology and Geriatrics” in the Russian Federation on the governmental level. Academic Council headed by V. Khavinson has oversighted over 200 Ph.D. and Doctorate theses from many different countries.

Prof. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Pinealon. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Prof. Vladimir Khavinson is listed in [1] [3] [5] [6] and [9] under the referenced citations.

References and Citations

[1] L. I. Fedoreyeva, I. I. Kireev, V. K. Khavinson, and B. F. Vanyushin, “Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA,” Biochem. Biokhimiia, vol. 76, no. 11, pp. 1210–1219, Nov. 2011.

[2] V. N. Meshchaninov, E. L. Tkachenko, S. V. Zharkov, I. V. Gavrilov, and I. E. Katyreva, “[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION],” Adv. Gerontol. Uspekhi Gerontol., vol. 28, no. 1, pp. 62–67, 2015.

[3] V. K. Khavinson, B. I. Kuznik, S. I. Tarnovskaya, and N. S. Lin’kova, “Short Peptides and Telomere Length Regulator Hormone Irisin,” Bull. Exp. Biol. Med., vol. 160, no. 3, pp. 347–349, Jan. 2016.

[4] K. S. Rana et al., “Plasma irisin levels predict telomere length in healthy adults,” Age Dordr. Neth., vol. 36, no. 2, pp. 995–1001, Apr. 2014.

[5] A. Arutjunyan, L. Kozina, S. Stvolinskiy, Y. Bulygina, A. Mashkina, and V. Khavinson, “Pinealon protects the rat offspring from prenatal hyperhomocysteinemia,” Int. J. Clin. Exp. Med., vol. 5, no. 2, pp. 179–185, 2012.

[6] V. Khavinson et al., “Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes,” Rejuvenation Res., vol. 14, no. 5, pp. 535–541, Oct. 2011.

[7] L. S. Kozina, “[Investigation of antihypoxic properties of short peptides],” Adv. Gerontol. Uspekhi Gerontol., vol. 21, no. 1, pp. 61–67, 2008.

[8] J. Zhang and W. Zhang, “Can irisin be a linker between physical activity and brain function?,” Biomol. Concepts, vol. 7, no. 4, pp. 253–258, Aug. 2016.

[9] V. K. Khavinson, N. S. Lin’kova, S. I. Tarnovskaya, R. S. Umnov, E. V. Elashkina, and A. O. Durnova, “Short peptides stimulate serotonin expression in cells of brain cortex,” Bull. Exp. Biol. Med., vol. 157, no. 1, pp. 77–80, May 2014.

[10] A. M. MendzheritskiÄ, V. Karantysh, G. A. Ryzhak, and S. V. Dem’ianenko, “[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon],” Adv. Gerontol. Uspekhi Gerontol., vol. 27, no. 1, pp. 94–97, 2014.

[11] “Serum Caspase-3 p17 Fragment Is Elevated in Patients With ST-Segment Elevation Myocardial Infarction | JACC: Journal of the American College of Cardiology.” [Online]. Available:

[Accessed: 11-Jun-2019].

[12] M. A. Voicekhovskaya, N. I. Chalisova, E. A. Kontsevaya, and G. A. Ryzhak, “Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats,” Bull. Exp. Biol. Med., vol. 152, no. 3, pp. 357–359, Jan. 2012.

[13] A. S. Bashkireva and V. G. Artamonova, “[The peptide correction of neurotic disorders among professional truck-drivers],” Adv. Gerontol. Uspekhi Gerontol., vol. 25, no. 4, pp. 718–728, 2012.


2 reviews for PINEALON (20 MG)

  1. Neil

    Every point of communication was great!! Very happy with their service. Also loved this PINEALON peptide.

  2. Samuel

    Pinealon has demonstrated potential in our research on brain health. Our test subjects have shown improved alertness and focus. Highly recommend for cognitive studies!

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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.